Nanion Technologies

Nanion Technologies - Smart Tools for Ion Channel Research, Drug Discovery, Automated Patch Clamp

"Automated formation of bilayer microarrays for single molecule detection with biological nanopores"

Dr. Gerhard Baaken, Ionera GmbH

"Investigating ion channel properties with the Orbit mini"
Dr. Mohamed Kreir, Application Scientist, Nanion Technologies

Introduction and moderation: Dr. Cecilia Farre, Marketing Director, Nanion Technologies


Orbits V1 flat 250pxThis webinar covers the use of the lipid bilayer platforms from Nanion: the Orbit16 and the Orbit mini for characterization of membrane proteins like ion channels, bacterial porins and biological nanopores. Both bilayer systems support high quality low noise recordings, but differ in throughput capabilities and experimental features. The Orbit16, introduced in 2012 is a device for efficient formation of 16 lipid bilayers simultaneously, allowing for parallel bilayer-reconstitution of ion channels and nanopores. Lipid bilayer arrays are automatically formed by remotely actuated painting. Orbit 16 has proven to be a versatile device for research and scientific applications which is reflected by numerous publication in high rank journals such as Science, Nature, Nano Letters, ACS Nano etc. The Orbit mini, introduced in 2015, is a smaller system, allowing low noise, high bandwidth recordings from 4 bilayers simultaneously. Orbit mini supports temperature-controlled experiments, allowing both active cooling and heating, a benefit when investigating thermo-sensitive channels such as TRPA1 or TRPV1, which will be shown in this webinar. Micro Electrode Cavity Array chips (MECA chips, Ionera Technologies GmbH, Freiburg) are the core of both devices. The MECA chips have successfully been validated with a wide variety of different ion channels and pores including KcsA, gramicidin, α-hemolysin, Kv- and Nav-channels etc. In this webinar the basics of the MECA technology will be explained and its applications will be shown in detail. Join this webinar and see how these outstanding platforms can add up to your work: Orbit 16 and Orbit mini!