Anoctamin-1 | ANO-1 | TMEM -16A

Family:
Calcium-dependent chloride channels (Ca-CIC or CaCC family)

Members:
CaCCs that are known to occur in humans are encoded by the following genes:
Accessories: CLCA1 - CLCA4
Anoctamins: ANO-1 and ANO-2
Bestrophins: BEST1 - BEST4

Topology:
CaCC channels are a heterogeneous groups of ligand-gated ion channels for chloride that have been identified in many epithelial and endothelial cell types as well as in smooth muscle cells, including proteins from several structurally different families: chloride channel accessory (CLCA), bestrophin (BEST), and calcium-dependent chloride channel anoctamin (ANO or TMEM16) channels. Members of the Ca-CIC family exhibit 7 to 10 transmembrane segments.

Application Notes

TMEM16A (ANO1) - "Internal perfusion of Ca2+ to activate TMEM16A/ANO1 on the SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE application note   logo pdf   (6.8 MB)
Cells were kindly provided by SB Drug Discovery.

 

 

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