Kir2.1 | Potassium Voltage-Gated Channel Subfamily J Member 2

Family:
Inward-rectifier potassium ion channel

Subgroups:
Seven families channels demonstrate robust inward rectification: Kir1.1; Kir2.1 - Kir2.4; Kir3.1 - Kir3.4, Kir4.1 - Kir4.2; Kir5.1, Kir6.1 - Kir6.2; Kir7.1

Topology:
The channel protein contains two membrane spanning alpha helices denoted as M1 and M2. Four identical subunits form a functional homotetramer, heterotetramers can combine with members of the same subfamily

 

Kir2.1 Background Information

Kir2.1 is a inward rectifier potassium channel which participates in establishing action potential waveform and excitability of neuronal and muscle tissues.

Gene:
KCNJ2

Human Protein:
UniProt P63252

Tissue:
Heart, peripheral nerves, brain, vascular smooth muscle cells, skeletal muscles, lung, placenta, kidney

Function/ Application:
Participates in establishing action potential waveform and excitability of neuronal and muscle tissues, mediates the IK1 current in the heart

Pathology:
Andersen-Tawil syndrome, Short QT syndrome 3, Autosomal dominant inheritance, Bidirectional ventricular ectopy, Blepharophimosis, Brachydactyly syndrome, Long QT syndrome 7 (LQT7), Atrial fibrillation familial, 9 (ATFB9), PiP2

Interaction:
Forms heterodimers with Kir2.2 and Kir4.1. Interacts with Kir2.3, DLG4, DLG1, CASK, APBA1, interleukin 16, TRAK2, LIN7A, LIN7B, LIN7C, AKAP5

Modulator:
Glyburide, Nicorandil, Cesium chloride, Tertiapin-Q, Glibenclamide, ML 133 hydrochloride, Barium chloride

Assays:
Patch clamp

Recommended Reviews:
Kubo et al. (2005) International Union of Pharmacology. LIV. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels. Pharmacol Rev 57(4):509-526

Poster

Application Notes

Cardiac Ion Channels - "High Throughput Screening of Cardiac Ion Channels"

icon sp96   SyncroPatch 384PE   icon pl   Patchliner   Icon CE   CardioExcyte 96 application note   logo pdf   (0.2 MB)

Cardiac Ion Channels - "Simultaneous Assessment of CiPA Stipulated Ion Channels on the SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE application note   logo pdf   (1.3 MB)
Cells were kindly provided by Charles River.

Publications

Webinars

27.06.2017 | Webinar: New Dynamics in Automated Patch Clamp

icon pl   Patchliner

This webinar shows new applications on dynamic patch clamp of iPSC-derived cardiomyocytes and introduces an assay on KCa3.1 expressed in erythrocytes

Contact Us

Please type your full name.
Invalid email address.
Invalid Input
Invalid Input
Nanion Technologies GmbH

Ganghoferstr. 70A
D-80339 Munich - Germany
info@nanion.de