Kir5.1 | Potassium Voltage-Gated Channel Subfamily J Member 16

Family:
Inward-rectifier potassium ion channel

Subgroups:
Seven families channels demonstrate robust inward rectification: Kir1.1; Kir2.1 - Kir2.4; Kir3.1 - Kir3.4, Kir4.1 - Kir4.2; Kir5.1, Kir6.1 - Kir6.2; Kir7.1

Topology:
The channel protein contains two membrane spanning alpha helices denoted as M1 and M2. Four identical subunits form a functional homotetramer, heterotetramers can combine with members of the same subfamily

 

Kir5.1 Background Information

Kir5.1 is a G-protein activated inward rectifier potassium channel, involved in the regulation of fluid and pH balance. In the kidney, together with Kir4.1, the channel mediates basolateral K+ recycling in distal tubules; this process is critical for Na+ reabsorption at the tubules.

Gene:
KCNJ16

Human Protein:
UniProt Q9NPI9

Tissue:
Widely expressed, with highest levels in adult and fetal kidney (in the proximal and distal convoluted tubules, not in glomeruli nor collecting ducts), in the brain the channel is expressed ind neurons and glial cells.

Function/ Application:
Mediates basolateral K+ recycling in distal tubules

Pathology:
Sesame Syndrome, Campomelic Dysplasia, Body dysmorphic disorder, corneal dystrophy, schnyder type, thyrotoxic periodic paralysis

Interaction:
Forms heteromers with Kir5.1. Interacts with Kir2.1 and Kir4.2 (may form heterodimers), Gamma-aminobutyric acid B receptor 1 and 2, GNB3, GNG13, GNGT1, Guanylate kinase 1, DLG2, GNGT2icorandil, Glyburide

Assays:
Patch clamp

Recommended Reviews:
Kubo et al. (2005) International Union of Pharmacology. LIV. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels. Pharmacol Rev 57(4):509-526

Publications

2016 - pH-sensitive K+ channel TREK-1 is a novel target in pancreatic cancer

icon sp96  SyncroPatch 384PE publication in Biochimica et Biophysica Acta (2016)

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