KV3.1 | Shaw Related Potassium Channel Member 1

Family:
Potassium channels

Subgroups:
Shaker (KV1.1–KV1.8), Shab (KV2.1-KV2.2), Shaw (KV3.1–KV3.4), Shal (KV4.1–KV4.3), KQT like (KV7.1–KV7.5), Eag related (KV10.1-KV10.2), Erg related (KV11.1–KV11.3), Elk related (KV12.1)

Topology:
Contains six transmembrane domains (S1–S6), four single subunits form a pore, homotetramers and heterotetramers are possible.

KV3.1 Background Information

KV3.1 belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. KV3.1 channels are prominently expressed in CNS neurons that fire at high frequency and are important for auditory and fast-spiking GABAergic interneurons, retinal ganglion cells; regulation of action potential duration in presynaptic terminals. KV3.1 can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of the ion channel.

Gene:
KCNC1

Human Protein:
UniProt P48547

Tissue:
Brain: cerebellum, retina, substantia nigra, cortical and hippocampal interneurons

Function/ Application:
Rapid repolarization of fast-firing brain neurons, involved in the regulation of the sleep–wake cycle

Pathology:
Progressive myoclonus epilepsy (EPM7), schizophrenia, spinocerebellar ataxia, cerebellar atrophy, myoclonus, autosomal dominant inheritance

Interaction:
Heteromultimer with KCNG3, KCNG4 and KCNV2, KCNE2, KCNC3. Interacts with KCNE1, KCNE2, Ankyrin 3, Calcium/calmodulin-dependent protein kinase II alpha, Voltage-dated sodium channel alpha subunit type V

Modulator:
4-AP, TEA, E-4031, linopirdine dihydrochloride, XE 991 dihydrochloride

Assays:
Patch Clamp: whole cell, temperature control, state-dependance

Recommended Reviews:
Gutman et al. (2005) International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev 57(4):473-508

Publications

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