• MscS

    MscS current traces from E. coli spheroblasts

MscS | Small Conductance Mechanosensitive Channel

Family:
Bacterial mechanosensitive channels, small conductance mechanosensitive channel family

Topology:
The MscS family is much larger and more variable in size and sequence than the MscL family. MscS family homologues vary in length between 248 and 1120 amino acyl residues and in topology, but the homologous region that is shared by most of them is only 200-250 residues long, exhibiting 4-5 transmembrane regions (TMSs).

Regulation and Function:
Members of the Small Conductance Mechanosensitive Ion Channel (MscS) Family provide protection against hypo-osmotic shock in bacteria, responding both to stretching of the cell membrane and to membrane depolarization. In eukaryotes, they fulfill a multitude of important functions in addition to osmoregulation. They are present in the membranes of organisms from the three domains of life: bacteria, archaea, fungi and plants.

Publications

2014 - Studying mechanosensitive ion channels with an automated patch clamp

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in European Biophysics Journal (2014)

2010 - Studying mechanosensitive ion channels using liposomes

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Methods in Molecular Biology (2010)

 

 

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