NaK - Non-selective Tetrameric Ion Channels

Family:
Non-selective Tetrameric Ion Channels

Topology:
The NaK channel is a homotetramer with each of the four identical subunits containing transmembrane helices (M1 and M2), an interfacial helix (M0), a pore helix (P), and a selectivity filter to conduct ions.

Function:
The NaK channel is prokaryotic non-selective tetrameric ion channel which conducts sodium (Na+) and potassium (K+) ions. The channel contains a transmembrane aqueous pore that transports ions through facilitated diffusion. It maintains the ionic flux across cell membranes with Na+ ions that depolarize the membrane potential and K+ ions that repolarize the membrane potential. The NaK channelcontrols biological functions including coordination of contraction and transport of metal ion cofactors of enzymes.

Publications

2016 - Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Nature Communications (2016)

Contact Us

Please type your full name.
Invalid email address.
Invalid Input
Invalid Input
Nanion Technologies GmbH

Ganghoferstr. 70A
D-80339 Munich - Germany
info@nanion.de