NaV1.2 | sodium voltage-gated channel alpha subunit 2

Family:
Sodium channels

Subgroups:
NaV1.1-1.9

Topology:
Alpha subunits consist of four homologous domains (I-IV) with six transmembrane alpha helices (S1–S6) and a pore-forming loop. One a subunit may associate with 1 or 2 b subunits to make up the channel.

NaV1.2: Background Information

NaV1.2 is primarily expressed in unmyelinated axons and dendrites. Besides other voltage gated sodium channels but predominately, NaV1.2 and NaV1.6 subunits are co-expressed within a single hair cell. NaV1.2 ion channels are regulated by neutrotransmitters that act through G-protein coupled receptors and activate protein kinase A such dopamine, acetylcholine and serotonin. NaV1.2 is sensitive to TTX.

Gene:
SCN2A

Human Protein:
UniProt Q99250

Tissue:
Brain (neurons, microglia), utricular hair cells, corti organ

Function/ Application:
Excitability of neurons, generation of action potentials

Pathology:
Autism, epilepsy (EIEE11, BFNIS), late ataxia, pain, myoclonus, multiple sclerosis, Seizures, benign familial infantile, 3, Ohtahara syndrome, Infantile Spasms

Interaction:
Ankyrin G, β1 subunit, β2 subunit, calmodulin, Nedd4-2

Modulator:
Tetrodotoxin, saxitoxin , β-scorpion toxin Css-IV, veratridine, α-scorpion toxin, ATX-II

Assays:
Patch Clamp: whole cell, room temperature, State- and use-dependence

Particularities:
Patch clamp: NaV channel analysis requires GigaOhm seals and a stable and low access resistance

Recommended Reviews:
International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels. Pharmacol Rev 57: 397–409, Catterall, et al. 2005 

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