NaV1.8 | sodium voltage-gated channel alpha subunit 10
Alpha subunits consist of four homologous domains (I-IV) with six transmembrane alpha helices (S1–S6) and a pore-forming loop. One a subunit may associate with 1 or 2 b subunits to make up the channel.
NaV1.8: Background Information
NaV1.8 is expressed specifically in the dorsal root ganglion (DRG), in unmyelinated, small-diameter sensory neurons called C-fibres, and is involved in nociception. C-fibres can be activated by noxious thermal or mechanical stimuli and thus can carry pain messages. The specific location of NaV1.8 in sensory neurons of the DRG may make it a key therapeutic target for the development of new analgesics and the treatment of chronic pain. NaV1.8 is a TTX-resistant sodium channel.
Brain (small diameter DRG neurons)
Excitability of neurons, nociceptive transmission
Neuropathic pain, Multiple Sclerosis
b1, b2, b3
p11, PDZD2 and syntrophin-associated serine/threonine kinase (SASTK), Contactin, CAP-1A
Tetrodotoxin, lidocaine, benzocaine, A-887826, A-803467
Patch Clamp: whole cell, room temperature, State- and use-dependence
NaV channel analysis requires GigaOhm seals and a stable and low access resistance
Recommended Reviews:International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels. Pharmacol Rev 57: 397–409, Catterall, et al. 2005
Data and Applications