P2X2 | P2X Purinoceptor 2

Family:
Purinergic Receptors P2X

Subgroups:
The P2X family belongs to the P2 receptors superfamily which has further been divided into five subclasses: P2X, P2Y, P2Z, P2U, and P2T. The ligand-gated purinergic receptor class P2X contains seven members (P2X1 - P2X7).

Topology:
One molecule is composed of only two transmembrane domains and contains a large extracellular loop and intracellular carboxyl and amino termini

Regulation and Function:
P2X receptors are ligand-gated ion channels and are activated by extracellular ATP. Greatly distributed in neurons and glial cells, P2X receptors mediate a large variety of responses including fast transmission at central synapses, contraction of smooth muscle cells, platelet aggregation, macrophage activation, and apoptosis.

Data and Applications

P2X2/ P2X3 - Application of ATP

P2X23 10uATPicon sp96   SyncroPatch 96 (a predecessor model of SyncroPatch 384PE) data and applications: 
Cells were kindly supplied by Evotec AG, Hamburg, Germany

Shown are three consecutive current responses of 1321 N1 cells expressing P2X2 / P2X3 receptors to 10 µM ATP. Cells were washed twice between compound applications (holding −80 mV). The data demonstrate the reproducability of the whole cell current responses.

Application Notes

P2X2 / P2X3 - "P2X2/3 receptors recorded on Nanion's Patchliner"

icon pl   Patchliner application note:   logo pdf   (0.4 MB)
Cells were kindly provided by Evotec.  

Publications

2011 - State-of-the-art automated patch clamp devices: heat activation, action potentials, and high throughput in ion channel screening

icon pap   Port-a-Patch,   icon pl  Patchliner and   icon sp96   SyncroPatch 96 (a predecessor model of SyncroPatch 384PE) publication in Frontiers in Pharmacology (2011)

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