• P2X4

    Averaged current traces from P2X4-WT (red), and P2X4-G135S (blue) in response to ATP (100 𝜇M), measured on the Patchliner

    Sadovnick et al. (2017)

P2X4 | P2X Purinoceptor 4

Family:
Purinergic Receptors P2X

Subgroups:
The P2X family belongs to the P2 receptors superfamily which has further been divided into five subclasses: P2X, P2Y, P2Z, P2U, and P2T. The ligand-gated purinergic receptor class P2X contains seven members (P2X1 - P2X7).

Topology:
One molecule is composed of only two transmembrane domains and contains a large extracellular loop and intracellular carboxyl and amino termini

Regulation and Function:
P2X receptors are ligand-gated ion channels and are activated by extracellular ATP. Greatly distributed in neurons and glial cells, P2X receptors mediate a large variety of responses including fast transmission at central synapses, contraction of smooth muscle cells, platelet aggregation, macrophage activation, and apoptosis.

Publications

2017 - Purinergic receptors P2RX4 and P2RX7 in familial multiple sclerosis

icon pl  Patchliner publication in Human Mutation (2017)

Contact Us

Please type your full name.
Invalid email address.
Invalid Input
Invalid Input
Nanion Technologies GmbH

Ganghoferstr. 70A
D-80339 Munich - Germany
info@nanion.de