• P2X7

    BzATP concentration response curve obtained from wild-type P2X7 receptors as measured on the Patchliner.

P2X7 | P2X Purinoceptor 7

Family:
Purinergic Receptors P2X

Subgroups:
The P2X family belongs to the P2 receptors superfamily which has further been divided into five subclasses: P2X, P2Y, P2Z, P2U, and P2T. The ligand-gated purinergic receptor class P2X contains seven members (P2X1 - P2X7).

Topology:
One molecule is composed of only two transmembrane domains and contains a large extracellular loop and intracellular carboxyl and amino termini

Regulation and Function:
P2X receptors are ligand-gated ion channels and are activated by extracellular ATP. Greatly distributed in neurons and glial cells, P2X receptors mediate a large variety of responses including fast transmission at central synapses, contraction of smooth muscle cells, platelet aggregation, macrophage activation, and apoptosis.

Data and Applications

P2X7 - Application of BzATP

P2X7icon pl   Patchliner data and applications:
Data are taken from Milligan C.J. et al., Nature Protocols, 2009, 4(2), 244-255.

BzATP concentration response curve obtained from wild-type P2X7 receptors. Data are fite to the Hill equation with an EC50 of 69.7 ± 7.5 μM. The inset show representative currents evoked by BzATP (3 − 100 μM). Holding potential was −60 mV.

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