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Collaborative Activities with Takara Bio Cellartis Clonetech

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15.07.2016 | 2nd Nanion Workshop (JP): Electrical physiology of iPS cells differentiated cardiomyocytes

User Meeting Venue: Nanion Technologies Tokyo site

The Workshop will be supported by Takara Bio Cellartis Clontech. During the workshop iPSC-derived cardiomyocytes will be shown on the CardioExcyte 96 and Port-a-Patch.

Cardiomyocytes - "Combining automated patch clamp, impedance and EFP of hiPSC-CMs"

Icon CE   CardioExcyte 96   icon sp96   SyncroPatch 3984PE   icon pl   Patchliner Application Note 
Cells kindly provided by Takara-Clonetech.

Cardiomyocytes - "Voltage and current clamp recordings of Cellartis hiPS-CM on Nanion’s Patchliner"

icon pl   Patchliner application note:   logo pdf   (0.5 MB)
Cells were kindly provided by Takara Bio Europe AB.  

Cardiomyocytes - Data from different cell providers

Icon CE   CardioExcyte different ProvidersCardioExcyte data and applications:
Cells were kindly provided by Axiogenesis, Cellular Dynamics, GE Healthcare, Pluriomics, ReproCell, Takara Bio Cellartis Clonetech.

The CardioExcyte 96 allows for
• Non-invasive, label-free measurements of beating cardiomyocyte networks
• 96 recording wells in parallel with 1 ms time resolution
• Quick experiments or long-term compound effects on cardiotoxicity
• Real-time access to beating parameters
• Outstanding software for data analysis and export
• Cost effcient consumables - 96-well format

Cardiomyocytes - Effects of sotalol on impedance (left) and EFP (right) signals of Cellartis Cardiomyocytes

Icon CE   CardioExcyte SotalolCardioExcyte data and applications:
Cells were kindly provided by Takara Bio Cellartis Clontech.

Impedance (left) and EFP signals (right) in control conditions (A) and 1 μM sotalol (B) are shown. 
Irregular beating can be observed in the presence of sotalol.

Cardiomyocytes - Effects of verapamil on impedance (left) and EFP (right) signals of Cellartis Cardiomyocytes

Icon CE   CardioExcyte VerapamilCardioExcyte data and applications:
Cells were kindly provided by Takara Bio Cellartis Clontech.

(A) Impedance (left) and EFP signals (right) in control conditions
(B) Upon application of 10 nM verapamil
(C) Upon application of 100 nM verapamil.
(D) The mean beats for impedance (left) and EFP (right) are shown in D

 

 

 

 

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