GlyR a3 | Glycine Receptor Alpha 3
Glycine receptors (cys-loop receptors)
The family has been devided into nicotinic acetylcholine receptors (ionotropic channels) and muscarinic acetymcholine receptors (metabotropic G-protein coupled receptors). Both subgroups are sensitive to acetylcholine.
As typical cys-loop receptors, glycine receptor subunits contain four transmembrane spanning domains TM1-TM4. Five subunits form a pore, homomeric and heteromeric combinations are possible. There are presently four known isoforms of the α-subunit (α1 - α4), encoded by the genes GLRA1 - GLRA4, and a single β-subunit (GLRB)
Data and Applications