Kir2.1 | Potassium Voltage-Gated Channel Subfamily J Member 2

Inward-rectifier potassium ion channel

Seven families channels demonstrate robust inward rectification: Kir1.1; Kir2.1 - Kir2.4; Kir3.1 - Kir3.4, Kir4.1 - Kir4.2; Kir5.1, Kir6.1 - Kir6.2; Kir7.1

The channel protein contains two membrane spanning alpha helices denoted as M1 and M2. Four identical subunits form a functional homotetramer, heterotetramers can combine with members of the same subfamily


Kir2.1 Background Information

Kir2.1 is a inward rectifier potassium channel which participates in establishing action potential waveform and excitability of neuronal and muscle tissues.


Human Protein:
UniProt P63252

Heart, peripheral nerves, brain, vascular smooth muscle cells, skeletal muscles, lung, placenta, kidney

Function/ Application:
Participates in establishing action potential waveform and excitability of neuronal and muscle tissues, mediates the IK1 current in the heart

Andersen-Tawil syndrome, Short QT syndrome 3, Autosomal dominant inheritance, Bidirectional ventricular ectopy, Blepharophimosis, Brachydactyly syndrome, Long QT syndrome 7 (LQT7), Atrial fibrillation familial, 9 (ATFB9), PiP2

Forms heterodimers with Kir2.2 and Kir4.1. Interacts with Kir2.3, DLG4, DLG1, CASK, APBA1, interleukin 16, TRAK2, LIN7A, LIN7B, LIN7C, AKAP5

Glyburide, Nicorandil, Cesium chloride, Tertiapin-Q, Glibenclamide, ML 133 hydrochloride, Barium chloride

Patch clamp

Recommended Reviews:
Kubo et al. (2005) International Union of Pharmacology. LIV. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels. Pharmacol Rev 57(4):509-526


Application Notes

Cardiac Ion Channels - "High Throughput Screening of Cardiac Ion Channels"

icon sp96   SyncroPatch 384PE   icon pl   Patchliner   Icon CE   CardioExcyte 96 application note   logo pdf   (0.2 MB)

Cardiac Ion Channels - "Simultaneous Assessment of CiPA Stipulated Ion Channels on the SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE application note   logo pdf   (1.3 MB)
Cells were kindly provided by Charles River.



27.06.2017 | Webinar: New Dynamics in Automated Patch Clamp

icon pl   Patchliner

This webinar shows new applications on dynamic patch clamp of iPSC-derived cardiomyocytes and introduces an assay on KCa3.1 expressed in erythrocytes

Contact Us

Please type your full name.
Invalid email address.
Invalid Input
Invalid Input
Nanion Technologies GmbH

Ganghoferstr. 70A
D-80339 Munich - Germany